HAPPY FATHER’S DAY!


 

 

SOME QUOTES FOR TODAY:

 

One night a father overheard his son pray: Dear God, Make me the kind of man my Daddy is. Later that night, the Father prayed, Dear God, Make me the kind of man my son wants me to be.

 

Sherman made the terrible discovery that men make about their fathers sooner or later… that the man before him was not an aging father but a boy, a boy much like himself, a boy who grew up and had a child of his own and, as best he could, out of a sense of duty and, perhaps love, adopted a role called Being a Father so that his child would have something mythical and infinitely important: a Protector, who would keep a lid on all the chaotic and catastrophic possibilities of life.
Tom Wolfe
The Bonfire of the Vanities

 

There are fathers who do not love their children, but there is no grandfather who does not adore his grandson.
Victor Hugo 

 

“I won’t lie to you, fatherhood isn’t easy like motherhood”

Dan Castellaneta

 

By the time a man realizes that maybe his father was right,
he usually has a son who thinks he’s wrong.
Charles Wadsworth 

 

“A father is a banker provided by nature.”
– French Proverb

 

The child had every toy his father wanted.”
– Robert C. Whitten

 

LEONTINE: An only son, Sir, might expect more indulgence
CROAKER: An only father, Sir, might expect more obedience
– Oliver Goldsmith 1728-1774 from The Good Natured Man

 

It is admirable for a man to take his son fishing, but there is a special place in heaven for the father who takes his daughter shopping.
John Sinor

 

We think our fathers fools, so wise we grow.
Our wiser sons, no doubt will think us so.
– Alexander Pope

 

 

When I was a boy of 14, my father was so ignorant I could hardly stand to have the old man around. But when I got to be 21, I was astonished at how much the old man had learned in seven years.

 

The father is always a Republican toward his son, and his mother’s always a democrat.
– Robert Frost

 

There are three stages of a man’s life: He believes in Santa Claus, he doesn’t believe in Santa Claus, he is Santa Claus.

 

Life was a lot simpler when what we honored was father and mother rather than all major credit cards.
– Robert Orben

April 25, DNA Day


 

‘We wish to suggest a structure for the salt of deoxyribose nucleic acid (D.N.A.).

This structure has novel features which are of considerable biological interest.”…

John Watson and Francis Crick in Molecular Structure of Nucleic Acids. A structure for deoxyribose nucleic acid.

Nature No. 4356, April 25, 1953

 

DNA Day also marks the completion of the Human Genome Project, the 13-year international effort that identified the order, or sequence, of more than 3 billion bases in human DNA. The Human Genome Project was finished in 2003, 50 years after Watson and Crick described DNA as a double helix. (Source: National  Library of Medicine)

 

 

 

I would like to invite you to see two presentations courtesy of the National Genome Research Institute, that, at different levels, present different aspects of Genetics research (the pictures are from the U.S. Department of Energy Genome Program’s Genome Management Information System -GMIS):

1.- How Proteins Are Made

 

 

2.- Single Nucleotide Polimorphism:

Making SNPs Make Sense

 

Additional interesting presentations can be found at:

Online Education Kit: Understanding the Human Genome Project

 

 

                                                                                       HAPPY DNA DAY!!!

 

About Dragon Metabolism (again).


Of course, the post “New lights on Dragon Metabolism”, posted on April 1st. was a joke for April Fools day. I invented

the whole Dragogenin issue!

Some clues that could have allowed the readers to detect that it was a joke:       

          The date of the release of the information, April 1st., is repeated three times along the post.

 

          The News Agency:  It is not Reuters, or UPI, or AP or AFP, but an imaginary AMP (Adenosin MonoPhosphate agency!).

 

          The place where the information was released: Nogare, an imaginary place, whose name is the name of the famous dragon movies “Eragon” written backwards.

 

          Komodo University: Of course, an imaginary University.

 

          The reference to imaginary, mythological creatures as ancient dragons that were living in Europe in the V -VII centuries.

 

          And of course, the note at the end of the post: “This post was released on April, 1st, 2009 (Happy A.F.)”, meaning Happy  April Fools!

 

Conclusions: Do not believe everything you read, mainly if it is on April Fools!

 

 

New Lights on Dragon Metabolism


 

AMP. – Nogare, April, 1st:  A scientific team of Komodo University has reported today the discovery of a gen, in the mitochondria of salivary glands of Komodo’s dragon, that apparently was the responsible of the release of thermal energy in ancient dragons.

 

This gen that is not expressed in nowadays dragons apparently codifies the production of Dragogenin, a multifunctional protein involved in the production of heat.

 

This protein was produced in the laboratories of Nogare branch of Komodo University, by the insertion of the gen in E. coli. This multifunctional protein is formed by three different subunits: Subunit DgA, which shows what have been called “a pseudo-NADH.H+ dehydrogenase activity”, subunit DgB, with an activity very similar to cytochrome oxidase, and DgC, a transmembrane protein that acts as channel used for the return of protons from the intermembane space to the mitochondrial matrix.

 

The NADH.H+ dehydrogenase activity of Dragonenin is very peculiar since it uses NADH.H+ as substrate but its mechanism of action is very similar to the mechanism of Complex III: it pumps protons to the intermembrane space and these protons return to the matrix through the “shortcut” channels of the transmembrane proteins (DgC), while the electrons released from the Hydrogens are transferred to the DgB subunit. Since these subunits have a similar activity to cytochrome oxidase, the electrons are eventually transferred to Oxygen.

 

Because of the high potential difference between the NADH.H+/NAD+ and the O2/O= systems, the reaction catalyzed by the Dragogenin releases a high amount of energy mainly in the form of heat, since the Dg-C shortcut channel acts as uncoupler, avoiding the use of the energy in the synthesis of ATP by Complex V.  It seems that the generated heat was enough to vaporize the saliva in the dragon’s mouth, so, in fact, these ancient dragons could burn someone with their breath, thought the generation of fire looks improbable.

 

Current Dragons with repressed Dragogenin gen: 

 

 

Weedy Sea Dragon

Weedy Sea Dragon

Draco Volans

Draco Volans

Draco Dussumieri

Draco Dussumieri

 

Representation of a ancient dragon that lived in Europe around V to VII centuries A.D. 

Note: This post was released on April, 1st, 2009 (Happy A.F.) 

Please, check this related post: About Dragon metabolism (again)