Q: About a patient with a glucagonoma.


Mouse Islet of Langerhans immunostained for Glucagon


Assume that you find a patient with a glucagon-secreting pancreatic tumor (glucagonoma). Which one of the following is most likely to result from hyperglucagonemia?


a)     Decreased lipolysis


b)     Hyperglycemia


c)      Increased muscle protein synthesis.


d)     Increased liver glycolytic rate


e)     Increased glycogenesis


Q: About Fructose 2,6 Bisphosphate (CM-24)




Which of the following sentences explain better the role of fructose  2,6-bisphosphate in glycolysis?


a) It antagonizes phosphofructokinase-1


b) It is an intermediate of glycolysis


c) It activates covalently  aldolase


d) It inhibits allosterically hexokinase


e) It allosterically activates phosphofructokinase-1

Biochemistry Question CM-22


A 15 year-old patient complains of painful muscle cramps when performing physical exercise, followed by stiffness and weakness, and excretion of wined colored urine. A muscle biopsy indicates a muscle glycogen concentration much higher than normal. Deficit of which of the following enzymes is most likely causing these problems in this patient?


a) Creatin kinase


b) ATP synthase


c) Glycogen phosphorylase


d) Glycogen synthase


e) Glucose 6 phosphatase


Biochemistry Question CM-21


A 13 year-old patient with Type I diabetes mellitus, home alone,  takes an insulin injection before lunch but then he gets concentrated in a videogame he is playing and does not eat. Approximately 3 hours later, he becomes sweat, shaky and confused. These symptoms have appeared as a consequence of:


a) increased glucagon release from the pancreas


b) decreased glucagon release from the pancreas


c) increased insulin  release from the pancreas


d) decreased insulin release from the pancreas


e) high sugar levels in blood


f) low sugar levels in blood