Total Oxidation of a 17 carbon fatty acid, including oxidation of the resulting Propionyl CoA


Let’s use the basic calculations described in previous posts about this issue:

 

Beta-oxidation of  fatty acids with an odd number of carbons.

 

Energetic balance of the total (and I mean total) oxidation of a fatty acid with an odd number of carbons.

  

Oxidation of a fatty acid with 17 atoms of carbon.

 

 

Activation of the fatty acid to Acyl CoA = -2 ATP

 

Number of rounds in the Beta oxidation

(17/2) -1.5 = 8.5-1.5 = 7

7 rounds x  5 ATP/ round = 35 ATP

 

Number of units of Acetyl CoA produced = 7 Acetyl CoA

7 Acetyl CoA x 12 ATP/Acetyl CoA  = 84 ATP

 

Propionyl CoA up to Succinyl CoA = -1ATP

 

Succinyl CoA up to Malate = 3 ATP

 

Malate up to Pyruvate (1 NADPH.H+)

 

Pyruvate up to Acetyl Co A = 3 ATP

 

Acetyl CoA oxidation in the Krebs Cycle = 12 ATP

 

Total of ATP (considering the total oxidation of Propionyl CoA converted to Malate and then from Malate to Pyruvate and then from Pyruvate to Acetyl CoA = -2 + 35 +84 -1 + 3 +3 +12 =  134 ATP

 

In summary  (following the equivalence of  1 NADH.H+ yielding 3 ATP in the Respiratory Chain and 1 FADH2 yielding 2 ATP):

 

-Calculate the number of rounds of the fatty acid in the Beta-oxidation:

  Number of rounds  = (Number of carbons/2) -1.5

 

-The number of Acetyl CoA is the same as the number of rounds

 

-Subtract 2 ATP that were used in the initial activation of the fatty acid.

 

-Multiply the number of rounds x 5 ATP/round.

 

-Multiply the number of Acetyl CoA x 12 ATP/Acetyl CoA.

 

-Add 17 ATP produced in the total oxidation of Propionyl CoA to CO2

 

 

To practice this kind of exercise, I suggest that you do the calculations using now  the criteria that considers that each NADH.H+ oxidized in the Respiratory Chain yields 2.5 ATP and each FADH2 yields 1.5 ATP

 

 

I am looking forward to see your answers and comments!!!

 

 

6 thoughts on “Total Oxidation of a 17 carbon fatty acid, including oxidation of the resulting Propionyl CoA

  1. Pingback: Γυαλισμα Αυτοκινητων

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