G. Stepanopoulos, a 21 year-old male patient, son of the president of the Greek association in your town, attend to your office because of the presence of dark urine and a slight yellow color in his skin. At the exam, you detect jaundice and splenomegaly. During the interview, the patient refers that a week ago, he had some “migraine” crisis during a few days and he began to take great quantity of analgesics.
The headaches disappeared but his skin and eyes became yellowish, a problem that he know have happened in his family when they ate some kind of beans, but that he had never experienced before.
A mutation in which of the following enzymes would be the most probable cause of this situation?
b) Glucose 6 phosphate dehydrogenase
c) Pyruvate quinase
d) Glutamate Oxalacetate Aminotransferase
f) Aldolase II
g) Glucuronyl transferase
h) Hem synthase
i) Hem oxidase