The case of the Greek Icteric Patient


Question CM-03



                                 Athens, Acropolis, Parthenon. Photo from Wallyg, Flickr




G. Stepanopoulos, a 21 year-old male patient, son of  the president of the Greek association in your town, attend to your office because of the presence of dark urine and a slight yellow color in his skin. At the exam, you detect jaundice and splenomegaly.  During the interview, the patient refers that a week ago, he had some “migraine” crisis during a few days and he began to take great quantity of analgesics.


The headaches disappeared but his skin and eyes became yellowish, a problem that he know have happened in his family when they ate some kind of beans, but that he had never experienced before.


A mutation in which of the following enzymes would be the most probable cause of this situation?


a)     Glucokinase


b)     Glucose 6 phosphate dehydrogenase


c)      Pyruvate quinase


d)     Glutamate Oxalacetate Aminotransferase


e)     Galactokinase


f)       Aldolase II


g)     Glucuronyl transferase


h)    Hem synthase


i)       Hem oxidase




3 thoughts on “The case of the Greek Icteric Patient

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