Krebs Cycle Extended Matching Questions.
(Another format you can expect to see in your Multiple Choice medical exams)
b) Alpha-ketoglutarate dehydrogenase
c) Citrate synthase
e) Isocitrate dehydrogenase
f) Malate dehydrogenase
g) Succinate dehydrogenase
h) Succinil Co A synthase
For each enzyme feature, select the most likely Krebs Cycle enzyme:
This enzyme catalyzes the SLP reaction of the Krebs Cycle in which GDP is phosphorylated to GTP.
This is the enzyme of the Krebs cycle that is most similar to pyruvate dehydrogenase.
The deficit of enzymes of the TCA cycle is rare, indicating the importance of this pathway for survival. Several cases, however, are on record in which there is a severe deficiency of the enzyme that catalyzes the interconversion between fumarate and malate. The patient is characterized by severe neurological impairment, encephalomyopathy, and dystonia developing soon after birth. Urine contains abnormal amounts of fumarate and other metabolites of Krebs Cycle. Which of the above enzymes would be deficient?