About Aspirin Mechanism of Action (LM-01)


 

                                    Aspirin Structure

Several thousands of tons of aspirin (acetylsalicilate) are consumed  each year all over the world for the relief of headaches, inflammed joint, pain in general and fever. Also, at low doses, in the prevention of heart attacks. The relief caused by aspirin in these conditions is based mainly in aspirin effects on eicosanoid metabolism. Aspirin binds covalently (and so act as an irreversible inhibitor) to this enzyme of eicosanoid metabolism:

a) Lipoxygenase

b) Thromboxane Synthase

c) Prostacycline Synthase

d) Prostaglandin Synthase

e) Phospholipase A2

 

 

Answer

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