Question (B-02): Arsenic Poisoning and Enzymes of the Central Metabolic Pathway


Question (B-02), Bioenergetics: Arsenic poisoning and Enzymes of the Central Metabolic Pathway

 

Most forms of arsenic are toxic, but the arsenite form is much more toxic than others. Arsenite forms a stable complex with enzyme-bound lipoic acid. For the most part, arsenic poisoning is explained by inhibition of those enzymes that require lipoic acid as a coenzyme. So, two important enzymes inhibited as a consequence of arsenic poisoning are:

 

a)     Citrate synthase and Pyruvate dehydrogenase

b)     Citrate synthase and Isocitrate dehydrogenase 

c)      Citrate synthase and alpha-keto glutarate dehydrogenase

d)     Isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase

e)     Pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.

f)       Pyruvate dehydrogenase and isocitrate dehydrogenase

 

 

Answer

 

BIOENERGETICS PUZZLE:

 

Can you find the metabolites of the Krebs Cycle in this puzzle?